Overview
Nicotinamide adenine dinucleotide (NAD+) is a fundamental coenzyme present in all living cells, playing a critical role in cellular energy metabolism, redox signalling, and DNA repair pathway regulation. As a substrate for sirtuins, PARPs, and CD38, it sits at the intersection of multiple cellular processes that are central to ageing, metabolic, and longevity research.
Nova Biolabs supplies NAD+ 500mg from UK domestic stock, HPLC-verified at >98% purity.
Key Research Areas
Sirtuin Pathway Research
NAD+ is a required substrate for sirtuin deacylase enzymes (SIRT1-7), which regulate gene expression, stress responses, and metabolic adaptation. NAD+ availability directly modulates sirtuin activity in cell studies.
PARP Activity Studies
Poly-ADP-ribose polymerases (PARPs) consume NAD+ during DNA damage response. NAD+ is used in research studying DNA repair kinetics, PARP enzyme activity, and the energy cost of DNA repair.
Cellular Energy Metabolism
As a key electron carrier in glycolysis, the TCA cycle, and oxidative phosphorylation, NAD+ is foundational to cellular bioenergetics research.
Ageing and Longevity Research
Declining NAD+ levels with age have generated significant research interest in its role in age-related metabolic decline and potential intervention strategies in cellular ageing models.
Product Specifications
| Format | Lyophilised powder |
| Quantity | 500mg per vial |
| Purity | >98% (HPLC verified) |
| Storage | Refrigerate at 2–8°C. Stable 24 months lyophilised. |
| Origin | UK domestic stock |
| Research use | In vitro / laboratory use only |