Overview
5-Amino-1MQ (5-amino-1-methylquinolinium) is a cell-permeable small molecule that acts as an inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that methylates nicotinamide and plays a role in regulating cellular NAD+ levels and one-carbon metabolism. Research into NNMT inhibition has grown significantly as the enzyme has been identified as a potential target in metabolic and adipogenesis research.
Nova Biolabs supplies 5-Amino-1MQ 50mg from UK domestic stock, HPLC-verified at >98% purity.
Key Research Areas
NNMT Inhibition Studies
5-Amino-1MQ is a selective NNMT inhibitor used in cell models to study the effects of NNMT enzyme suppression on NAD+ metabolism, one-carbon cycling, and methylation homeostasis.
NAD+ Metabolism Research
By inhibiting NNMT, 5-Amino-1MQ affects the availability of nicotinamide for NAD+ biosynthesis. Research investigates this relationship in metabolic cell models.
Adipogenesis Research
NNMT expression is elevated in adipose tissue — 5-Amino-1MQ is used in adipocyte differentiation models to study the role of NNMT in fat cell development and lipid accumulation.
One-Carbon Metabolism
NNMT consumes methyl groups in the methylation of nicotinamide, affecting the cellular methyl pool. 5-Amino-1MQ is used to study how NNMT inhibition affects one-carbon metabolism and methylation reactions.
Product Specifications
| Format | Lyophilised powder |
| Quantity | 50mg per vial |
| Purity | >98% (HPLC verified) |
| Storage | Refrigerate at 2–8°C. Stable 24 months lyophilised. |
| Origin | UK domestic stock |
| Research use | In vitro / laboratory use only |